Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice
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چکیده
منابع مشابه
Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice
OBJECTIVE The enteroendocrine hormone glucagon-like peptide 1 (GLP-1) is an attractive anti-diabetic therapy. Here, we generated a recombinant Lactococcus lactis strain genetically modified to produce GLP-1 and investigated its ability to improve glucose tolerance in mice on chow or high-fat diet (HFD). METHODS We transformed L. lactis FI5876 with either empty vector (pUK200) or murine GLP-1 ...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2016
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2016.06.006